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Maternal Low-Calorie Sweeteners Consumption Rewires Hypothalamic Melanocortin Circuits via a Gut Microbial co-metabolite Pathway

The prevalence of obesity and type 2 diabetes is growing at an alarming rate, including among pregnant women. Low-calorie sweeteners (LCSs) have increasingly been used as an alternative to sugar to deliver a sweet taste without the excessive caloric load. However, there is little evidence regarding their biological effects, particularly during development. Here, we used a mouse model of maternal LCS consumption to explore the impact of perinatal LCS exposure on the development of neural systems involved in metabolic regulation. Read More

Influence of technical and maternal-infant factors on the measurement and expression of extracellular miRNA in human milk

Breast milk contains thousands of bioactive compounds including extracellular vesicle microRNAs (EV-miRNAs), which may regulate pathways such as infant immune system development and metabolism. We examined the associations between the expression of EV-miRNAs and laboratory variables (i.e., batch effects, sample characteristics), sequencing quality indicators, and maternal-infant characteristics. Read More

Relationship closeness as a protective factor against the sensitizing effect of adversity history

Exposure to adversity has been shown to amplify individuals’ sensitivity to stress, increasing the risk of developing mental health problems in adulthood. Romantic relationships can serve as a broad resource in mitigating the negative impacts of adversity and stress on mental health; however, less is known about how everyday moments of closeness with one’s romantic partner impact experiences of daily stress for people exposed to adversity. Read More

Human milk EV-miRNAs: a novel biomarker for air pollution exposure during pregnancy

Exposure to ambient and near-roadway air pollution during pregnancy has been linked with several adverse health outcomes for pregnant women and their babies. Emerging research indicates that microRNA (miRNA) expression can be altered by exposure to air pollutants in a variety of tissues. Additionally, miRNAs from breast tissue and circulating miRNAs have previously been proposed as a biomarker for breast cancer diagnosis and prognosis. Read More

Applying ecological systems theory to juvenile legal system interventions outcomes research: a measurement framework

Intervention research and development for youth in the juvenile legal system (JLS) has often focused on recidivism as the primary outcome of interest. Although recidivism is an important outcome, it is ultimately a downstream marker of success and is affected by changes in other domains of youths’ lives (e.g., family and peer relations, neighborhood safety, local and state-level policies). Thus, the present manuscript proposes the application of ecological systems theory to selecting outcomes to assess intervention effects in JLS intervention research to better capture proximal and distal influences on youth behavior. Read More

The Promise of Racial Healing to Achieve Health Equity Through School-Based Prevention

In the wake of the American Public Health Association’s formal declaration of racism as a public health crisis, there is an urgent need for more approaches to promoting the socioemotional well-being of K–12 Black, Indigenous, people of color (BIPOC) students, educators, and families. Cumulative exposures and reexposures to direct and indirect acts of racism can adversely affect emotion regulation and the ability to sustain meaningful relationships, disrupting socioemotional health and well-being. Read More