{"id":311,"date":"2023-02-16T22:29:57","date_gmt":"2023-02-17T06:29:57","guid":{"rendered":"https:\/\/dornsife.usc.edu\/bci\/?page_id=311"},"modified":"2026-06-24T10:10:36","modified_gmt":"2026-06-24T17:10:36","slug":"cenec-center-for-the-neuroscience-of-embodied-cognition","status":"publish","type":"page","link":"https:\/\/dornsife.usc.edu\/bci\/cenec-center-for-the-neuroscience-of-embodied-cognition\/","title":{"rendered":"CeNEC – Center for the Neuroscience of Embodied Cognition"},"content":{"rendered":"\n\n \n \n\n\n\n\n\n\n\n
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\"\"<\/p>\n

Our bodies are one of the most fundamental ways we understand ourselves, the world, and other people. Our metaphors relay this knowledge: we feel with our gut; we love with our heart; we toss ideas as if with our hands.<\/p>\n

Our program explores the idea that rudimentary sensory-motor brain regions, which may have been originally designed for processing our own body states, may be intrinsically involved in processing aspects of higher cognition. These include language, thought, emotions, empathy, and social understanding.<\/p>\n

For more information please visit the CeNEC Website<\/a>.<\/p>\n

Our current projects are as follows:<\/p>\n

From Sensory-Motor to Social in Autism Spectrum Disorder (ASD):<\/strong>\u00a0Children with ASD often have both motor and sensory deficits in addition to the social deficits that are the hallmark of the disorder.\u00a0 However the neurological basis of how those sensorimotor deficits relate to the core social deficits is poorly understood.\u00a0 Here we compare motor deficits in ASD to motor deficits in Developmental Coordination Disorder (DCD). Similarly, we compare sensory deficits in ASD to sensory deficits in Sensory Processing Disorder (SPD). In this way, we hope to better understand the relationship between sensory-motor processing to social deficits in ASD.\u00a0 This work is supported by an NIH R01 grant.
\nTo participate in this study, please see: <\/em>https:\/\/chan.usc.edu\/minds<\/a><\/p>\n

Relationship between the Gut Microbiome, the Brain, and Behavior: <\/strong>The gut has three times more neurons than the spinal cord, and most of those connections send information from the gut to the brain. Much of the signaling in the gut comes from metabolites produced by the gut microbiome. However the relationship between the gut microbiome, the brain, and behavior is poorly understood. Here we try to better understand this relationship in both typically developing individuals as well as individuals with ASD. This work is supported by a grant from the Department of Defense.
\nTo participate in this study, please see: <\/em>https:\/\/chan.usc.edu\/minds<\/a><\/p>\n

Embodied Semantics and communication:\u00a0<\/strong> Most of our metaphors are embodied: we \u201chandle\u201d situations; we \u201ckick-off\u201d a new year; we \u201cchew over\u201d decisions. Using fMRI and behavioral studies we explore how language processing involves sensorimotor brain representations. We investigate both literal and metaphorical language. This work has been funded by IARPA and NIH.<\/p>\n

Otherness and Belonging:\u00a0<\/strong>Belonging is a fundamental relationship grounded in the interaction<\/i> between an organism and its world. It is always a multi-directional relation<\/i> where the world includes the social, physical, emotional, and cultural environment available to the organism. For human beings, belonging is a critical factor both in the creation and in the perception of meaning in life. It is just as important as food or water for our survival and well-being. A lack of belonging is an existential breakage in a human being\u2019s relationship to their environment and to the world, and is a fundamental human need (Maslow, 1943). From an evolutionary perspective, the predisposition to belong is central to human existence and culture. Personality traits that motivate individuals to gain acceptance and avoid rejection are indispensable tools enabling survival and reproduction.<\/p>\n

The goal of the current project is to understand the basic science underlying the human need and the multiple dimensions of belonging, and to provide data on bridging strategies that mitigate the feeling of otherness. Data generated by this project will inform intervention strategies. It is a collaboration between the USC CeNEC lab, the UC Berkeley Othering and Belonging Institute<\/a>, and Google.<\/p>\n\n\n\n<\/div>\n\n\n <\/div><\/div>\n\n\n\n\n \n \n\n\n\n\n\n\n\n

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Publications<\/span><\/h4>\n

2026<\/p>\n

Kadambi A, Aziz-Zadeh L, Damasio A, Iacoboni M, Narayanan S. Embodiment in multimodal large language models. Neuron. 2026 Jun 3;114(11):1908-1921. doi: 10.1016\/j.neuron.2026.03.004. Epub 2026 Apr 1. PMID: 41928508.<\/span><\/p>\n

Ringold SM, Cermak SA, Labus JS, Mayer EA, Aziz-Zadeh L. Sensory Over-Responsivity in Autism: A Bidirectional Brain-Gut-Microbiome Model. J Autism Dev Disord. 2026 Mar 4. doi: 10.1007\/s10803-026-07279-3. Epub ahead of print. PMID: 41779338.<\/span><\/p>\n

2025<\/p>\n

Nadler EO, Guilbeault D, Ringold SM, Williamson TR, Bellemare-Pepin A, Com\u0219a IM, Jerbi K, Narayanan S, Aziz-Zadeh L. Statistical or Embodied? Comparing Colorseeing, Colorblind, Painters, and Large Language Models in Their Processing of Color Metaphors. Cogn Sci. 2025 Jul;49(7):e70083. doi: 10.1111\/cogs.70083. PMID: 40621800.<\/span><\/p>\n

Aziz-Zadeh L, Ringold SM, Jayashankar A, Kilroy E, Butera C, Jacobs JP, Tanartkit S, Mahurkar-Joshi S, Bhatt RR, Dapretto M, Labus JS, Mayer EA. Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology. Nat Commun. 2025 Apr 14;16(1):3465. doi: 10.1038\/s41467-025-58459-1. PMID: 40229237; PMCID: PMC11997199.<\/span><\/p>\n

Butera C, Delafield-Butt J, Lu SC, Sobota K, McGowan T, Harrison L, Kilroy E, Jayashankar A, Aziz-Zadeh L. Motor Signature Differences Between Autism Spectrum Disorder and Developmental Coordination Disorder, and Their Neural Mechanisms. J Autism Dev Disord. 2025 Jan;55(1):353-368. doi: 10.1007\/s10803-023-06171-8. PMID: 38062243; PMCID: PMC11802596.<\/span><\/p>\n

2024<\/p>\n

Loureiro F, Ringold SM, Aziz-Zadeh L. Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data. Psychol Res Behav Manag. 2024 May 3;17:1841-1853. doi: 10.2147\/PRBM.S410605. PMID: 38716258; PMCID: PMC11075678.<\/span><\/p>\n

Shipkova M, Butera CD, Flores GD, Kilroy E, Jayashankar A, Harrison L, Cermak SA, Aziz-Zadeh L. Caregiver and youth inter-rater assessment agreement in autism spectrum disorder, developmental coordination disorder, and typical development.\u00a0<\/span>Autism Res. 2024 Mar;17(3):610-625. doi: 10.1002\/aur.3110. Epub 2024 Mar 7. PMID: 38450955; PMCID: PMC11022856.<\/span><\/p>\n

Abrams G, Jayashankar A, Kilroy E, Butera C, Harrison L, Ring P, Houssain A, Nalbach A, Cermak SA, Aziz-Zadeh L. Differences in Praxis Errors in Autism Spectrum Disorder Compared to Developmental Coordination Disorder.\u00a0<\/span>J Autism Dev Disord. 2024 Mar;54(3):1113-1129. doi: 10.1007\/s10803-022-05858-8. Epub 2022 Dec 14. PMID: 36515853.<\/span><\/p>\n

Miller HL, Licari MK, Bhat A, Aziz-Zadeh LS, Van Damme T, Fears NE, Cermak SA, Tamplain PM. Motor problems in autism: Co-occurrence or feature? Dev Med Child Neurol. 2024 Jan;66(1):16-22. doi: 10.1111\/dmcn.15674. Epub 2023 Jun 18. PMID: 37332143; PMCID: PMC10725993.<\/span><\/p>\n

 <\/p>\n

Investigators<\/span><\/h3>\n

Lisa Aziz-Zadeh, PhD<\/p>\n

Aditya “AJ” Jayashankar, MS<\/p>\n

Sofronia Ringold, BA<\/p>\n<\/div>\n\n\n\n<\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":281,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-311","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nCeNEC - Center for the Neuroscience of Embodied Cognition - Brain and Creativity Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dornsife.usc.edu\/bci\/cenec-center-for-the-neuroscience-of-embodied-cognition\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CeNEC - Center for the Neuroscience of Embodied Cognition - Brain and Creativity Institute\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dornsife.usc.edu\/bci\/cenec-center-for-the-neuroscience-of-embodied-cognition\/\" \/>\n<meta property=\"og:site_name\" content=\"Brain and Creativity Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-24T17:10:36+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/dornsife.usc.edu\\\/bci\\\/cenec-center-for-the-neuroscience-of-embodied-cognition\\\/\",\"url\":\"https:\\\/\\\/dornsife.usc.edu\\\/bci\\\/cenec-center-for-the-neuroscience-of-embodied-cognition\\\/\",\"name\":\"CeNEC - 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