Susan L. Forsburg

STS Faculty

Professor of Biological Sciences

Phone: (213) 740-7342
Office: RRI 104C
Professor Forsburg studies how chromosome duplication and maintenance contributes to overall genome stability in a model genetic system, the fission yeast Schizosaccharomyces pombe. Fission yeast is a simple, single-celled organism with chromosomes very similar to those in humans, and has proven to be an important model for cell division. Loss of genome integrity and deregulation of cell division is associated with cancer, so this is a fundamental form of cancer research. Forsburg takes a holistic approach to studying the contribution of DNA replication proteins to genome stability. Ongoing studies address the role of the MCM helicase in maintaining the structure of the replication fork; the function of recombination and repair proteins in maintaining genome structure during S phase, including during meiosis; and the contribution of chromatin-modifying proteins to replication and repair. The lab has a developing interest in understanding the links between DNA replication and the formation and function of the centromere. Forsburg’s group employs advanced imaging methods to complement their classical genetics, including live-cell studies with fluorescent proteins in real time, as well as application using fixed cells including observation of proteins on chromosome spreads and imaging of chromatin fibers.

Anne Balsamo
Daniela Bleichmar
K. C. Cole
Manuel Castells
Antonio Damasio
Susan Forsburg
G. Clinton Godart
Deborah Harkness
Katie Hasson
Andrew Lakoff
Dan Lainer-Vos
Paul Lerner
Shrikanth Narayanan
John Brooks Slaughter
Mark Thompson