Advancing

Molecular Designs of new Medicines

We are an interdisciplinary team committed to unlocking the full potential of structural biology to treat human diseases.

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A new approach

Imagine a world

Where scientific data is released from the confines of its originating discipline allowing us to better understand, integrate, and advance knowledge. Over the past century, the sciences, engineering, and medicine have become progressively more specialized, each diverging into an array of sub-disciplines.

Our Mission
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Current research

Pancreatic Beta Cell

The pancreatic beta cell was chosen not only because its function is critical to human health as the body's sole source of insulin, but also because it has been extensively experimentally characterized, mathematically modelled, and simulated - all data that can be leveraged.

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Past Research Projects

G protein-coupled receptors

GPCRs are major contributors to the information flow into cells and, as such, are associated with a multitude of diseases that make members of this family important pharmacological targets.

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Phenylketonuria

Mutations in the gene encoding for PheOH is responsible for the metabolic disorder phenylketonuria (PKU), or the milder form, hyperphenylalaninemia (HPA).

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Joint Center for Innovative Membrane Protein Technologies

The Joint Center for Innovative Membrane Protein Technologies-Complexes (JCIMPT-Complexes) is a research network comprising multiple integrated biophysical projects.

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Botulinum Toxin

Clostridial neurotoxins are responsible for disrupting neurotransmission. They include tetanus toxin and the 7 serotypes of botulinum toxin.

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Endocannabinoid Signaling

In collaboration with The Scripps Research Insititute, we solved the structure of FAAH, a degradative integral membrane enzyme responsible for setting intracellular levels of endocannabinoids, to 2.8 Å.

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“Development of this dynamic model will accelerate the creation and implementation of novel therapies and cures for a host of intractable diseases and conditions.”

Raymond Stevens