Genome Stability and Instability and the Repair of Chromosome Breaks

Dr. James Haber, Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University

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Friday, April 18, 2014 18/04/2014 12:00:00 18/04/2014 23:59:59 6 Genome Stability and Instability and the Repair of Chromosome BreaksUniversity Park Campus
12:00 PM
University Park Campus
Ray R. Irani Hall (RRI)
101
213-821-4464

Although our cells experience several chromosome breaks each time they replicate their DNA, the genome is remarkably stable – with the notable exception of cancer cells and other disease states that show many chromosomal rearrangements, truncations and copy number variation.  Using budding yeast as a model system, we have explored the fidelity – and infidelity – of repairing double-strand chromosome breaks induced by a site-specific endonuclease.  We find that the repair process is surprisingly prone to specific kinds of replication-associated errors leading to template switches ranging from simple frame shifts to dramatic interchromosomal template switches and microhomology-mediated rearrangements.

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