Awarded to a small number of professors who, because of their multi-disciplinary interests and significant accomplishments in several disciplines, qualify for an appointment that transcends any single field of study. Generally, a faculty member accorded this title also has a tenured faculty appointment in a specific academic unit.
| Leo Braudy | University Professor and Leo S. Bing Chair in English and American Literature and Professor of English |
| Antonio Damasio | University Professor, David Dornsife Chair in Neuroscience and Professor of Psychology and Neurology |
| Hanna Damasio | University Professor, Dana Dornsife Chair in Neuroscience and Professor of Psychology and Neurology |
| Dick Easterlin | University Professor and Professor of Economics |
| Thomas Jordan | University Professor and W.M. Keck Foundation Chair in Geological Sciences |
| Marsha Kinder | University Professor and Professor of Critical Studies, Comparative Literature and Spanish and Portuguese |
| Richard Thompson | University Professor Emeritus and William M. Keck Chair Emeritus in Psychology and Biological Sciences |
| Michael Waterman | University Professor, USC Associates Chair in Natural Sciences and Professor of Biological Sciences, Computer Science and Mathematics |