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Scott Edward Kanoski

Assistant Professor of Biological Sciences

Contact Information
E-mail: kanoski@usc.edu
Phone: (213) 740-2495
Office: PED 107

 

Education
Ph.D. Psychology / Behavioral Neuroscience, Purdue University, 8/2009
M.S. Psychology, Purdue University, 5/2006
B.S. Psychology, University of Illinois at Urbana-Champaign, 5/2000
 

Postdoctoral Training
Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009-12/31/2012  
 

Academic Appointment, Affiliation, and Employment History
Assistant Professor, University of Southern California, 01/01/2013-  
 

Description of Research

Summary Statement of Research Interests
Dr. Scott Kanoski’s research focuses on the neurophysiological control of food intake and body weight regulation. More specifically his interests are centered on understanding how the brain processes peripherally-derived neuroendocrine signals (e.g., leptin, ghrelin, GLP-1) to control learned and motivational aspects of feeding behavior, as well as how these neuroendocrine systems contribute to and are compromised by obesity and metabolic disorders. Dr. Kanoski's lab also focuses on understanding how obesity and consumption of unhealthy "Western diets" contribute to the development of cognitive impairment and Alzheimer's pathology.
 

Research Keywords
obesity, energy balance, hormone receptors, neuropeptides, high-fat diet, learning & memory, gastrointestinal signals, Alzheimer's
 

Research Specialties
Behavioral Neuroscience, Ingestive Behavior, Energy Balance, Endocrinology, Learning & Memory, cognitive impairment
 

Affiliations with Research Centers, Labs, and Other Institutions
USC Diabetes and Obesity Research Institute (DORI)
USC Neuroscience Graduate Program (NGP)
 

Conferences and Other Presentations

Conference Presentations
"Hippocampal Contributions of the Control of Food Intake", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Atlanta, GA, Invited, 2013-2014   
"Satiation and Reward", The Benjamin Franklin Lafayette Seminar, Talk/Oral Presentation, Frejus, France, Invited, 2013-2014   
"Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Zurich, Switzerland, 2012-2013   
"How your gut tells your brain you have eaten enough: role for glucagon-like peptide-1", American Pediatric Society (Annual Meeting), Talk/Oral Presentation, Boston, MA, Invited, 2012-2013   
"Leptin signaling in the nucleus tractus solitarius suppresses motivation to obtain rewarding food", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, San Antonio, TX, 2012-2013   
"Western diets and cognitive impairment: neuronal and psychological mechanisms", American Psychological Association (Annual Meeting), Talk/Oral Presentation, Orlando, FL, Invited, 2012-2013   
"Body weight and food intake suppression by glucagon-like peptide-1 receptor agonists, exendin-4 and liraglutide, may require nausea and aversion", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Orlando, FL, 2011-2012   
"Neurohormonal and dietary influences on hippocampal-dependent inhibitory controls of food intake", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Clearwater, FL, Invited, 2011-2012   
"Vagal and brain GLP-1 receptor populations mediate the hypophagic effects of peripheral GLP-1 receptor agonists", The Obesity Society (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Orlando, FL, 2011-2012   
"Hippocampal leptin signaling reduces food intake and body weight and influences appetitive spatial memory", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Pittsburg, PA, 2010-2011   
"The impact of Western diet intake on memory and blood-brain barrier integrity in rats", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Portland, OR, 2009-2010   
"The effects of high-energy diets on modulatory learning processes", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Paris, France, 2008-2009   
"Interoceptive signals and postingestive consequences produced by regulatory peptides", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Steamboat Springs, CO, 2007-2008   
"The impact of high-fat diets on hippocampal-dependent learning processes", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Naples, FL, 2006-2007   
"The hippocampus and energy regulation", The Society for the Study of Ingestive Behavior (Annual Meeting), Talk/Oral Presentation, Refereed Abstract, Pittsburg, PA, 2005-2006   
 

Publications

Journal Article
Kanoski, S. E., Fortin, S. M., Ricks, K. M., Grill, H. J. (2012). Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling. Biological psychiatry. PubMed Web Address
Kanoski, S. E., Zhao, S., Guarnieri, D. J., Dileone, R. J., Yan, J., De Jonghe, B. C., Bence, K. K., Hayes, M. R., Grill, H. J. (2012). Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. American journal of physiology. Endocrinology and metabolism. Vol. 303 (4), pp. E496-503. PubMed Web Address
De Jonghe, B. C., Hayes, M. R., Kanoski, S. E., Zimmer, D. J., Grill, H. J., Bence, K. K. (2012). Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American journal of physiology. Endocrinology and metabolism. PubMed Web Address
Kanoski, S. E. (2012). Cognitive and neuronal systems underlying obesity. Physiology & behavior. Vol. 106 (3), pp. 337-44. PubMed Web Address
Spaeth, A. M., Kanoski, S. E., Hayes, M. R., Grill, H. J. (2012). TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. American journal of physiology. Endocrinology and metabolism. Vol. 302 (10), pp. E1252-60. PubMed Web Address
Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C., Hayes, M. R. (2012). The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Neuropharmacology. Vol. 62 (5-6), pp. 1916-27. PubMed Web Address
Zhao, S., Kanoski, S. E., Yan, J., Grill, H. J., Hayes, M. R. (2012). Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. International Journal of Obesity. PubMed Web Address
McKay, N. J., Kanoski, S. E., Hayes, M. R., Daniels, D. (2011). Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (6), pp. R1755-64. PubMed Web Address
Hayes, M. R., Kanoski, S. E., De, B. C., Leichner, T. M., Alhadeff, A. L., Fortin, S. M., Arnold, M., Langhans, W., Grill, H. J. (2011). The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (5), pp. R1479-85. PubMed Web Address
Kanoski, S. E., Fortin, S. M., Arnold, M., Grill, H. J., Hayes, M. R. (2011). Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology. Vol. 152 (8), pp. 3103-12. PubMed Web Address
Kanoski, S. E., Hayes, M. R., Greenwald, H. S., Fortin, S. M., Gianessi, C. A., Gilbert, J. R., Grill, H. J. (2011). Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. Vol. 36 (9), pp. 1859-70. PubMed Web Address
Hayes, M. R., Kanoski, S. E., Alhadeff, A. L., Grill, H. J. (2011). Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. Obesity (Silver Spring, Md.). Vol. 19 (7), pp. 1342-9. PubMed Web Address
De Jonghe, B. C., Hayes, M. R., Banno, R., Skibicka, K. P., Zimmer, D. J., Bowen, K. A., Leichner, T. M., Alhadeff, A. L., Kanoski, S. E., Cyr, N. E., Nillni, E. A., Grill, H. J., Bence, K. K. (2011). Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American journal of physiology. Endocrinology and metabolism. Vol. 300 (6), pp. E1002-11. PubMed Web Address
Kanoski, S. E., Davidson, T. L. (2011). Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiology & behavior. Vol. 103 (1), pp. 59-68. PubMed Web Address
Hayes, M. R., Leichner, T. M., Zhao, S., Lee, G. S., Chowansky, A., Zimmer, D., De, B. C., Kanoski, S. E., Grill, H. J., Bence, K. K. (2011). Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell metabolism. Vol. 13 (3), pp. 320-30. PubMed Web Address
Hayes, M. R., Valmer, J., De Jonghe, B. C., Kanoski, S. E. (2010). Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiology & behavior. Vol. 100 (5), pp. 503-10. PubMed Web Address
Kanoski, S. E., Davidson, T. L. (2010). Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet. Journal of experimental psychology. Animal behavior processes. Vol. 36 (2), pp. 313-9. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Chan, K., Clegg, D. J., Benoit, S. C., Jarrard, L. E. (2010). Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behavioral neuroscience. Vol. 124 (1), pp. 97-105. PubMed Web Address
Kanoski, S. E., Zhang, Y., Zheng, W., Davidson, T. L. (2010). The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. Journal of Alzheimer's disease : JAD. Vol. 21 (1), pp. 207-19. PubMed Web Address
Davidson, T. L., Chan, K., Jarrard, L. E., Kanoski, S. E., Clegg, D. J., Benoit, S. C. (2009). Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus. Vol. 19 (3), pp. 235-52. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Schier, L. A., Clegg, D. J., Benoit, S. C. (2007). A potential role for the hippocampus in energy intake and body weight regulation. Current opinion in pharmacology. Vol. 7 (6), pp. 613-6. PubMed Web Address
Kanoski, S. E., Meisel, R. L., Mullins, A. J., Davidson, T. L. (2007). The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. Vol. 182 (1), pp. 57-66. PubMed Web Address
Kanoski, S. E., Walls, E. K., Davidson, T. L. (2007). Interoceptive "satiety" signals produced by leptin and CCK. Peptides. Vol. 28 (5), pp. 988-1002. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Walls, E. K., Jarrard, L. E. (2005). Memory inhibition and energy regulation. Physiology & behavior. Vol. 86 (5), pp. 731-46. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Tracy, A. L., Walls, E. K., Clegg, D., Benoit, S. C. (2005). The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. Peptides. Vol. 26 (9), pp. 1602-10. PubMed Web Address
 

Honors and Awards
National Research Service Award (NIDDK), 2010-2013  
Ethan Sims Young Investigator Award (The Obesity Society), Fall 2012   
Early Career Research Grant (The Obesity Society), 2010-2011   
Bilsland Fellowship, 2008-2009   
Gerry P. Smith Award (Society for the Study of Ingestive Behavior), 2008-2009   
 

Service to the Profession

Editorships and Editorial Boards
Associate Editor, Journal of Alzheimer's Disease, 2011-2012   
 

Professional Memberships
The Obesity Society, 2010-  
The Society for Neuroscience (SFN), 2004-  
The Society for the Study of Ingestive Behavior, 2004-  
 

Other Service to the Profession
Reviewer for Biotechnology and Biological Sciences Research Council (BBSRC), United Kingdom, 12/01/2012-  
Scientific Review Committee Member (The Obesity Society), 2012-  
 
Faculty may update their profile by visiting https://mydornsife.usc.edu.