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Scott Kanoski

Assistant Professor of Biological Sciences

Contact Information
E-mail: kanoski@usc.edu
Phone: (213) 740-2495
Office: PED 107

LINKS
Personal Website
 

Education

Ph.D. Psychology / Behavioral Neuroscience, Purdue University, 8/2009
M.S. Psychology, Purdue University, 5/2006
B.S. Psychology, University of Illinois at Urbana-Champaign, 5/2000
 

Postdoctoral Training

Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009-12/31/2012  
 

Academic Appointment, Affiliation, and Employment History

Tenure Track Appointments

Assistant Professor, University of Southern California, 01/01/2013-  
 

PostDoctoral Appointments

Postdoctoral Research Fellow, University of Pennsylvania, 08/01/2009-12/31/2012  
 

Description of Research

Summary Statement of Research Interests

Dr. Kanoski’s research focuses on the neurobiological control of food intake and body weight regulation. More specifically his laboratory focuses on understanding how the brain processes peripherally- and centrally-derived hormonal signals to control learned and motivated aspects of feeding behavior, as well as to examine how these neuroendocrine signaling systems contribute to and are compromised by obesity and related metabolic disorders. At the center of this research is the hippocampus; a brain region traditionally linked with memory function, but more recently shown to control higher-order aspects of feeding behavior. The lab also focuses on exploring the relationship between consuming saturated fatty acids and refined carbohydrates (i.e., "Western diets") and the development of hippocampal dysfunction, cognitive impairment, and Alzheimer's pathology.
 

Research Specialties

Behavioral Neuroscience, Ingestive Behavior, Energy Balance, Neuroendocrinology, Learning & Memory, Systems Neuroscience
 

Affiliations with Research Centers, Labs, and Other Institutions

Integrative and Evolutionary Biology Graduate Program, Faculty Member, https://dornsife.usc.edu/bisc/heb-graduate-studies/
Society for Neuroscience, Faculty Member, http://www.sfn.org/
Society for the Study of Ingestive Behavior, Faculty Member, http://www.ssib.org/web/
The Obesity Society, Faculty Member, http://www.obesity.org/
USC Diabetes and Obesity Research Institute (DORI), Faculty Member, http://usc-dori.org/
USC Neuroscience Graduate Program (NGP), Faculty Member, https://ngp.usc.edu/
 

Publications

Book Chapter

Davidson, T. L., Sample, C. H., Kanoski, S. E. (2014). Western diet and cognitive impairment. Diet and Nutrition: Dementia and Cognitive Decline (Elsevier).
Kanoski, S. E., Hsu, T., Pennell, S. (2014). Obesity, Western diet intake, and cognitive impairment. Fat and Fatty Acids: Brain and Neurological Health (Elsevier).
Kanoski, S. E. (2012). Working memory and diet. Working Memory: The Connected Intelligence (Psychology Press / Taylor & Francis).
 

Journal Article

Kanoski, S. E., Ong, Z., Fortin, S. M., Schlessinger, E., Grill, H. J. (2015). Liraglutide, leptin, and their combined effects on feeding: additive intake reduction through common intracellular signaling mechanisms. Diabetes, Obesity and Metabolism. Vol. 17 (3), pp. 285-93. PubMed Web Address
Hsu, T. M., Konanur, V. R., Taing, L., Usui, R., Kayser, B. D., Goran, M. I., Kanoski, S. E. (2015). Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus. PubMed Web Address
Hsu, T. M., Hahn, J. D., Konanur, V. R., Lam, A., Kanoski, S. E. (2015). Hippocampal GLP-1 receptors influence food intake and effort-based responding for food through volume transmission. Neuropsychopharmacology. PubMed Web Address
Ozek, C., Kanoski, S. E., Zhang, Z., Grill, H. J., Bence, K. K. (2014). Protein tyrosine phosphatase 1B is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B signaling. Journal of Biological Chemistry. Vol. 289 (46), pp. 31682-92. PubMed Web Address
Hsu, T., Kanoski, S. E. (2014). Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. Frontiers in Aging Neuroscience. Vol. 6 (88) PubMed Web Address
Kanoski, S. E., Alhadeff, A. L., Fortin, S. F., Gilbert, J. R., Grill, H. J. (2014). Leptin signaling in the medial nucleus tractus solitarius reduces food seeking and willingness to work for food. Neuropsychopharmacology. Vol. 39 (3), pp. 605-613. PubMed Web Address
Hayes, M. R., Mietlicki-Baase, E. G., Kanoski, S. E., De Jonghe, B. C. (2014). Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose. Nutrition Reviews. Vol. IN PRESS
Kanoski, S. E., Fortin, S. M., Ricks, K. M., Grill, H. J. (2013). Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling. Biological psychiatry. Vol. 73 (9), pp. 915-23. PubMed Web Address
Kanoski, S. E., Zhao, S., Guarnieri, D. J., Dileone, R. J., Yan, J., De Jonghe, B. C., Bence, K. K., Hayes, M. R., Grill, H. J. (2012). Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. American journal of physiology. Endocrinology and metabolism. Vol. 303 (4), pp. E496-503. PubMed Web Address
De Jonghe, B. C., Hayes, M. R., Kanoski, S. E., Zimmer, D. J., Grill, H. J., Bence, K. K. (2012). Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American journal of physiology. Endocrinology and metabolism. PubMed Web Address
Kanoski, S. E. (2012). Cognitive and neuronal systems underlying obesity. Physiology & behavior. Vol. 106 (3), pp. 337-44. PubMed Web Address
Spaeth, A. M., Kanoski, S. E., Hayes, M. R., Grill, H. J. (2012). TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin. American journal of physiology. Endocrinology and metabolism. Vol. 302 (10), pp. E1252-60. PubMed Web Address
Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C., Hayes, M. R. (2012). The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Neuropharmacology. Vol. 62 (5-6), pp. 1916-27. PubMed Web Address
Zhao, S., Kanoski, S. E., Yan, J., Grill, H. J., Hayes, M. R. (2012). Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. International Journal of Obesity. PubMed Web Address
McKay, N. J., Kanoski, S. E., Hayes, M. R., Daniels, D. (2011). Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (6), pp. R1755-64. PubMed Web Address
Hayes, M. R., Kanoski, S. E., De, B. C., Leichner, T. M., Alhadeff, A. L., Fortin, S. M., Arnold, M., Langhans, W., Grill, H. J. (2011). The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. American journal of physiology. Regulatory, integrative and comparative physiology. Vol. 301 (5), pp. R1479-85. PubMed Web Address
Kanoski, S. E., Fortin, S. M., Arnold, M., Grill, H. J., Hayes, M. R. (2011). Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology. Vol. 152 (8), pp. 3103-12. PubMed Web Address
Kanoski, S. E., Hayes, M. R., Greenwald, H. S., Fortin, S. M., Gianessi, C. A., Gilbert, J. R., Grill, H. J. (2011). Hippocampal leptin signaling reduces food intake and modulates food-related memory processing. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. Vol. 36 (9), pp. 1859-70. PubMed Web Address
Hayes, M. R., Kanoski, S. E., Alhadeff, A. L., Grill, H. J. (2011). Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats. Obesity (Silver Spring, Md.). Vol. 19 (7), pp. 1342-9. PubMed Web Address
De Jonghe, B. C., Hayes, M. R., Banno, R., Skibicka, K. P., Zimmer, D. J., Bowen, K. A., Leichner, T. M., Alhadeff, A. L., Kanoski, S. E., Cyr, N. E., Nillni, E. A., Grill, H. J., Bence, K. K. (2011). Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American journal of physiology. Endocrinology and metabolism. Vol. 300 (6), pp. E1002-11. PubMed Web Address
Kanoski, S. E., Davidson, T. L. (2011). Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiology & behavior. Vol. 103 (1), pp. 59-68. PubMed Web Address
Hayes, M. R., Leichner, T. M., Zhao, S., Lee, G. S., Chowansky, A., Zimmer, D., De, B. C., Kanoski, S. E., Grill, H. J., Bence, K. K. (2011). Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell metabolism. Vol. 13 (3), pp. 320-30. PubMed Web Address
Hayes, M. R., Valmer, J., De Jonghe, B. C., Kanoski, S. E. (2010). Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiology & behavior. Vol. 100 (5), pp. 503-10. PubMed Web Address
Kanoski, S. E., Davidson, T. L. (2010). Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet. Journal of experimental psychology. Animal behavior processes. Vol. 36 (2), pp. 313-9. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Chan, K., Clegg, D. J., Benoit, S. C., Jarrard, L. E. (2010). Hippocampal lesions impair retention of discriminative responding based on energy state cues. Behavioral neuroscience. Vol. 124 (1), pp. 97-105. PubMed Web Address
Kanoski, S. E., Zhang, Y., Zheng, W., Davidson, T. L. (2010). The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. Journal of Alzheimer's disease : JAD. Vol. 21 (1), pp. 207-19. PubMed Web Address
Davidson, T. L., Chan, K., Jarrard, L. E., Kanoski, S. E., Clegg, D. J., Benoit, S. C. (2009). Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus. Vol. 19 (3), pp. 235-52. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Schier, L. A., Clegg, D. J., Benoit, S. C. (2007). A potential role for the hippocampus in energy intake and body weight regulation. Current opinion in pharmacology. Vol. 7 (6), pp. 613-6. PubMed Web Address
Kanoski, S. E., Meisel, R. L., Mullins, A. J., Davidson, T. L. (2007). The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural brain research. Vol. 182 (1), pp. 57-66. PubMed Web Address
Kanoski, S. E., Walls, E. K., Davidson, T. L. (2007). Interoceptive "satiety" signals produced by leptin and CCK. Peptides. Vol. 28 (5), pp. 988-1002. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Walls, E. K., Jarrard, L. E. (2005). Memory inhibition and energy regulation. Physiology & behavior. Vol. 86 (5), pp. 731-46. PubMed Web Address
Davidson, T. L., Kanoski, S. E., Tracy, A. L., Walls, E. K., Clegg, D., Benoit, S. C. (2005). The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation. Peptides. Vol. 26 (9), pp. 1602-10. PubMed Web Address
 
 
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