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Matthew Michael

Associate Professor of Biological Sciences

Contact Information
E-mail: mattm@usc.edu
Phone: (213) 740-0553
Office: RRI 104B

LINKS
Curriculum Vitae
 

Education

Ph.D. Molecular Biology, University of Pennsylvania, 1996
A.B. Genetics, U.C. Berkeley, 1986
 

Postdoctoral Training

Daymon Runyon Fellow, U.C. San Diego, 1996-2000  
 

Description of Research

Summary Statement of Research Interests

The lab studies biochemical mechanisms of cell cycle control, as well as how cell cycle timing is integrated with developmental mechanisms during early embryonic development. We are interested in mechanisms for cell cycle checkpoint activation, mechanisms of translesion DNA synthesis, and how DNA replication, DNA repair, and cell cycle progression pathways interact during a replication stress response. We are also interested in how cell cycle checkpoints regulate the timing of early embryonic cell divisions, and how the nucleus-to-cytoplasmic ratio is sensed to control cell behavior during early development. The organisms that we use for our studies include cell-free extracts prepared from the eggs of the frog Xenopus laevis, the nematode Caenorhabditis elegans, and mammalian tissue culture cells.
 

Research Keywords

cell cycle control, DNA replication, translesion synthesis, cell cycle checkpoints, checkpoint signaling during early embryonic development, biochemistry, cell biology, genetics
 
 
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