University of Southern California
USC Dana and David Dornsife College of Letters, Arts and Sciences
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About
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Matthew MichaelAssociate Professor of Biological SciencesContact Information E-mail: mattm@usc.edu Phone: (213) 740-0553 Office: RRI 104B |
Education |
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 Ph.D. Molecular Biology, University of Pennsylvania, 1996
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A.B. Genetics, U.C. Berkeley, 1986
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Postdoctoral Training |
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Daymon Runyon Fellow, U.C. San Diego, 1996-2000
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Description of Research |
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Summary Statement of Research Interests |
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| The lab studies biochemical mechanisms of cell cycle control, as well as how cell cycle timing is integrated with developmental mechanisms during early embryonic development. We are interested in mechanisms for cell cycle checkpoint activation, mechanisms of translesion DNA synthesis, and how DNA replication, DNA repair, and cell cycle progression pathways interact during a replication stress response. We are also interested in how cell cycle checkpoints regulate the timing of early embryonic cell divisions, and how the nucleus-to-cytoplasmic ratio is sensed to control cell behavior during early development. The organisms that we use for our studies include cell-free extracts prepared from the eggs of the frog Xenopus laevis, the nematode Caenorhabditis elegans, and mammalian tissue culture cells. | |
Research Keywords |
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| cell cycle control, DNA replication, translesion synthesis, cell cycle checkpoints, checkpoint signaling during early embryonic development, biochemistry, cell biology, genetics | |
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