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Steven Finkel

Professor of Biological Sciences

Contact Information
E-mail: sfinkel@usc.edu
Phone: (213) 821-1498
Office: RRI 319B

 

Education

Ph.D. Biological Chemistry, University of California, Los Angeles, 1994
B.A. Molecular Biology, University of California, Berkeley, 1987
 

Postdoctoral Training

Helen Hay Whitney Foundation Postdoctoral Research Fellow, Microbiology & Molecular Genetics, Harvard Medical School, 1994-1999  
 

Academic Appointment, Affiliation, and Employment History

Professor of Biological Sciences, University of Southern California, 2013-  
Distinguished Fellow, USC Center for Excellence in Teaching, 2012-  
Reader, The Huntington Library, 2011-  
Deputy Director, USC Center for Excellence in Genomic Science, USC, 2009-  
Member, USC/Norris Comprehensive Cancer Center, 2000-  
Dornsife Faculty Fellow, USC Dornsife College of Letters, Arts and Sciences, 2011-2013  
Associate Professor of Biological Sciences, University of Southern California, 2007-2013  
Fellow, USC Center for Excellence in Teaching, 2009-2012  
ASM Distinguished Lecturer, American Society for Microbiology, 2009-2011  
Assistant Professor of Biological Sciences, University of Southern California, 2000-2007  
 

Description of Research

Summary Statement of Research Interests

Reseach in Professor Finkel’s laboratory focuses on the long-term survival and evolution of bacteria, including understanding natural systems and applications to electricity production. Among the topics of current study in the laboratory are (1) the mechanisms of survival in many organisms, including population structure at the genetic & genomic level and studies of the GASP (growth advantage in stationary phase) phenotype; (2) the generation of bacterial diversity in different environments, including the roles of error-prone DNA polymerases in generating diversity; (3) the role of DNA-protein interactions in controlling gene expression, organizing the chromosome, and protecting DNA during the stationary phase of the bacterial lifecycle, focusing on the role of the Dps protein, (4) the use of DNA as a nutrient and parallels to natural competence and transformation; and (5) the long-term survival ability of bacteria in electricity-generating microbial fuel cells (MFCs). Model organisms in the laboratory include: Escherichia coli, Shewanella oneidensis, Pseudomonas aeruginosa, and Streptococcus mutans.
 

Affiliations with Research Centers, Labs, and Other Institutions

Alzheimer's Disease Research Center, http://www.usc.edu/dept/gero/ADRC/
Cellular, Biochemical, and Molecular Sciences (CBM) NIH Training Grant, http://www.usc.edu/programs/pibbs/site/nih_training_grant.html
Center for Deep Energy Biosphere Investigations, http://www.darkenergybiosphere.org/
Center of Excellence in Genomic Science, Deputy Director, http://cegs.cmb.usc.edu/
Dark Energy Biosphere Institute-Research Coordination Network, http://www.darkenergybiosphere.org/
PIBBS - Programs in Biomedical and Biological Sciences, USC, http://www.usc.edu/programs/pibbs/
USC Geobiology, http://geobiology.usc.edu/
USC/Norris Comprehensive Cancer Center, http://ccnt.usc.edu
 

Publications

Book Chapter

Finkel, S. E. (2012). An accidental evolutionary biologist: GASP, long-term survival and evolution. Microbes and Evolution: The World That Darwin Neve pp. pp.115-122. Washington, DC: ASM Press.
Finkel, S. E., Zinser, E., Kolter, R. (2000). Long-term survival and evolution in stationary phase. pp. p. 231-238. Bacterial Stress Responses/ASM.
Finkel, S. E., Zinser, E., Gupta, S., Kolter, R. (1998). Life and Death in Stationary Phase. (Vol. 103). pp. 3-16. NATO-ASI Series, Series H: Cell Biology/Springer-Verlag.
 

Journal Article

Corzett, C. H., Goodman, M. F., Finkel, S. E. (2013). Competitive Fitness During Feast and Famine: How SOS DNA Polymerases Influence Physiology and Evolution in Escherichia coli. Genetics. Vol. 194, pp. 409-420.
Riedel, T. E., Berelson, W. M., Nealson, K. H., Finkel, S. E. (2013). Oxygen Consumption Rates of Bacteria Under Nutrient-Limited Conditions. Applied Environ. Microbiol.. pp. Epub ahead of print.
El-Naggar, M. Y., Finkel, S. E. (2013). Live Wires. The Scientist. Vol. 27
Yamanaka, K., Minko, I. G., Finkel, S. E., Goodman, M. F., Lloyd, R. S. (2011). The role of high fidelity E. coli DNA polymerase I in the replication bypass of deoxyadenosine DNA-peptide cross-link. J. Bacteriol. Vol. 193, pp. 3815-3821. PubMed Web Address
Nealson, K. H., Finkel, S. E. (2011). Electron flow and biofilms. MRS Bulletin. Vol. 36, pp. 380-382.
Gonidakis, S., Finkel, S. E., Longo, V. D. (2011). Lifespan extension and paraquat resistance in a ubiquinone-deficient E. coli mutant depend on transcription factors ArcA and TdcA. Aging. Vol. 3, pp. 291-303.
Biffinger, J., Fitzgerald, L., Ray, R., Little, B., Lizewski, S., Petersen, E., Ringeisen, B., Sanders, W., Sheehan, P., Pietron, J., Baldwin, J., Nadeau, L., Johnson, G., Ribbens, M., Finkel, S. E., Nealson, K. H. (2011). The utility of Shewanella japonica for microbial fuel cells. Bioresour. Technol.. Vol. 102, pp. 290-297.
Pepper, E. D., Farrell, M. J., Nord, G., Finkel, S. E. (2010). Anti-glycation effects of carnosine and other compounds on long-term survival of Escherichia coli. Appl. Environ.Microbiol.. Vol. 76, pp. 7925-7930.
Gondakis, S., Finkel, S. E., Longo, V. D. (2010). Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell. Vol. 9, pp. 868-881.
Gonidakis, S., Finkel, S. E., Longo, V. D. (2010). E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyle-CoA synthetase. Biol. Chem.. Vol. 391, pp. 1139-1147.
Palchevskiy, V., Finkel, S. E. (2009). A role for single-stranded exonucleases in the use of DNA as a nutrient. J. Bacteriol.. Vol. 191, pp. 3712-3716.
Biffinger, J. C., Ray, R., Little, B. J., Fitzgerald, L. A., Ribbens, M. A., Finkel, S. E., Ringeisen, B. R. (2009). Simultaneous analysis of physiological and electrical output changes in an operating microbial fuel cell with Shewanella oneidensis. Biotechnol. Bioeng.. Vol. 103, pp. 524-531.
Kraigsley, A., Finkel, S. E. (2009). Adaptive evolution in single species biofilms. FEMS Microbiology Letters. Vol. 293, pp. 135-140.
Ren, C., Finkel, S. E., Tower, J. (2009). Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. Exp. Gerontol.. Vol. 44, pp. 228-235.
Biffinger, J., Ribbens, M., Pietron, J., Finkel, S. E., Nealson, K. (2009). Characterization of electrochemically active bacteria (EAB) utilizing a high-throughput voltage-based screening assay. Biotechnol. Bioeng.. Vol. 102, pp. 436-444.
Kumari, A., Minko, I. G., Harbut, B., Finkel, S. E., Goodman, M. F., Lloyd, R. S. (2008). Replication bypass of interstrand crosslink intermediates by Escherichia coli DNA polymerase IV. J. Biol. Chem.. Vol. 283, pp. 27433-27437.
Ren, C., Webster, P., Finkel, S. E., Tower, J. (2007). Increased internal and external bacterial load during Drosophila aging without life span trade-off. Cell Metabolism. Vol. 6, pp. 144-152.
Skvortsov, D., Abdueva, D., Stitzer, M. E., Finkel, S. E., Tavaré, S. (2007). Using expression arrays for copy number detection: an example from E. coli. BMC Bioinformatics. Vol. 8, pp. 203.
Stevens, M. H., Sanchez, M., Lee, J., Finkel, S. E. (2007). Diversification rates increase with population size and resource concentration in an unstructured habitat. Genetics. Vol. 177, pp. 2243-2250.
Pepper, E. D., Farrell, M. J., Finkel, S. E. (2006). Role of penicillin binding protein 1b in competitive stationary phase survival and antibiotic resistance. FEMS Microbiology Letters. Vol. 263, pp. 61-67.
Finkel, S. E. (2006). Long-term survival during stationary phase: Evolution and the GASP phenotype. Nature Reviews Microbiology. Vol. 4, pp. 113-120.
Finkel, S. E., Petrie, A., Erbe, J. (2005). Use of long-term E. coli cultures to study generation of genetic diversity and teach general microbiology laboratory skills. American Biology Teacher. pp. p.87-92.
Nair, S., Finkel, S. E. (2004). Dps protects cells against multiple stresses during stationary phase. Journal of Bacteriology/ASM. Vol. 186, pp. 4192-4198.
Farrell, M. J., Finkel, S. E. (2003). The growth advantage in stationary phase phenotype conferred by rpoS mutations is dependent on pH and nutrient source. Journal of Bacteriology/ASM. Vol. 185, pp. 7044-7052.
Yeiser, B., Pepper, E. D., Goodman, M. F., Finkel, S. E. (2002). SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness. Proc. Natl. Acad. Sci. USA. Vol. 99, pp. 8737-8741.
Finkel, S. E., Kolter, R. (2001). DNA as a nutrient: A novel role for bacterial competence gene homologs. J. Bacteriol.. Vol. 183, pp. 6288-6293.
Finkel, S. E., Kolter, R. (1999). Evolution of microbial diversity during prolonged starvation. Proc. Natl. Acad. Sci. USA. Vol. 96, pp. 4023-4027.
 

Multimedia Scholarship and Creative Works

Mentor, USC-IML Certificate Program, 2007-2008   
 

Honors and Awards

USC Center for Excellence in Teaching, Faculty Fellow, 2009-2012  
American Society for Microbiology Branch Lecturer, 2009-2011  
NIH/NSF Career Development Award, NSF Faculty Early Career Award, 2003-2009  
USC-Mellon Award for Excellence in Mentoring Undergraduates, 2007-2008   
Visiting Scholar Award, Alberta Heritage Foundation for Research, 2004-2005  
 

Service to the Profession

Editorships and Editorial Boards

Editor, Research in Microbiology, 2011-  
Editorial Board, Journal of Bacteriology, 2010-  
Editorial Board, Applied and Environmental Microbiology, 2008-  
Section Editor, EcoSal: Escherichia coli and Salmonella Cellular & Molecular Biology, 2003-  
Editor, Biochemical Journal, 2006-2009  
 

Professional Memberships

The Biochemical Society (U.K), 2007-  
American Association for the Advancement of Science, 2000-  
American Society for Microbiology, 1987-  
 
 
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