Fabien PinaudAssistant Professor of Biological Sciences, Chemistry and Physics and Astronomy
Phone: (213) 740-2262
Office: RRI 204A
- B.S. Biomedical Sciences, Nottingham Trent University (UK), 6/1999
- Ph.D. Biochemistry and Molecular Biology, University of California Los Angeles, 6/2007
- Marie Curie and EMBO Post-Doctoral Fellow, Ecole Normale Supérieure, Departments of Biology and Physics, Paris (France), 07/01/2007-07/01/2011
- Assistant Professor in Biological Sciences and Chemistry, University of Southern California, 08/16/2011-
- Assistant Professor / Joint Appointment Faculty, USC Chemistry Department, 2011-2012
- Member, USC Norris Comprehensive Cancer Center, 2011-2012
Academic Appointment, Affiliation, and Employment History
Tenure Track Appointments
Visiting and Temporary Appointments
Description of Research
Summary Statement of Research Interests
Detailed Statement of Research Interests
The lab studies how spatially defined nanoscale subcellular compartments influence the diffusion, the location, the interactions, and thus the activity of biomolecules in living cells and tissues. We are particularly interested in understanding how plasma and nuclear membrane scaffolds, microdomains and cavities modulate the diffusion and the activity of proteins involved in normal and pathogenic intracellular signaling. At the nanoscale, membrane compartments can accommodate discrete biomolecular interactions that deviate from the classical laws of mass action at the ensemble level, thereby allowing few copies of biomolecules to influence whole cell processes.
To resolve the spatial organization and the dynamics of such nanoscale processes involving so few biomolecules, we employ a variety of laser-based single molecule fluorescence techniques such as super-resolution microscopy imaging by PALM or dSTORM, single protein tracking using fluorophores, fluorescent proteins and quantum dots or FRET imaging. These techniques allow us to image nanoscale compartments, track signaling proteins and detect biomolecular interactions in cells with a spatial resolution of a few nanometers.
We also develop new ultra-sensitive imaging probes that quantitatively report and influence such nanoscale interactions in both living cells and animals. Some of these probes, based on nanoparticle surface engineering and photonic amplification, will have direct applications for cancer cell targeting, detection and treatment.
Our group is highly interdisciplinary as we work at the interface between cell and molecular biology, biological chemistry, biophysics, nanomaterial sciences and optical imaging. By merging ideas and tools from these different fields, we seek to gain new insight into the molecular mechanisms that govern nanostructures/protein function relationships in the context of signal processing, integration and regulation during cellular decision-making. We also aim at providing advanced nanoprobes for cancer diagnostics and therapeutics.
- Department of Biological Sciences
- University of Southern California
- Allan Hancock Foundation Building
- Los Angeles, CA 90089-0371
- Phone: (213) 740 - 1109
- Email: firstname.lastname@example.org