MCB Faculty

Oscar Aparicio

Professor of Biological Sciences

Contact Information
Phone: (213) 821-1269
Office: RRI 219B



  • B.S. Microbiology, University of Florida, 5/1987
  • Ph.D. Molecular Genetics & Cell Biology, University of Chicago, 12/1993

  • Postdoctoral Training

    • Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  

    Academic Appointment, Affiliation, and Employment History

    Tenure Track Appointments
    • Associate Professor, University of Southern California, 05/01/2005-  
    • Assistant Professor, University of Southern California, 09/01/1999-05/01/2005  
    PostDoctoral Appointments
    • Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  
    Other Employment
    • Congressional Science Fellow, American Society for Microbiology, 09/01/1993-08/31/1994  

    Description of Research

    Summary Statement of Research Interests
    The Aparicio lab studies the mechanisms of cell cycle and checkpoint regulation of chromosomal DNA replication as well as how the three-dimensional organization and chromatin structure of chromosomes regulates this process. We use cell biological, molecular, biochemical, genetic, and genomic approaches using the model organism, S. cerevisiae (aka: Baker’s yeast). We have recently identified the Forkhead Box (Fox) proteins Fkh1 and Fkh2 as regulators of replication origin initiation, and are investigating their role in regulating the dynamics and three-dimensional organization of chromosomes. We also work on the development of methods to study genomic activities such as protein-DNA interactions that underlie fundamental processes such as DNA replication and epigenetic control.
    Research Keywords
    DNA replication, genome dynamics and structure, chromatin, checkpoints, cell cycle, replication origins, replication forks, budding yeast, S. cerevisiae
    Research Specialties
    Biochemistry, Molecular Biology, DNA replication, Genetics, S. cerevisiae

    Affiliations with Research Centers, Labs, and Other Institutions

    • USC/Norris Comprehensive Cancer Center, Member,

  • Department of Biological Sciences
  • University of Southern California
  • Allan Hancock Foundation Building
  • Los Angeles, CA 90089-0371