MCB Faculty

Oscar Aparicio

Professor of Biological Sciences

Contact Information
E-mail: oaparici@usc.edu
Phone: (213) 821-1269
Office: RRI 219B

 

Education

  • B.S. Microbiology, University of Florida, 5/1987
  • Ph.D. Molecular Genetics & Cell Biology, University of Chicago, 12/1993


  • Postdoctoral Training

    • Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  

    Academic Appointment, Affiliation, and Employment History

    Tenure Track Appointments
    • Associate Professor, University of Southern California, 05/01/2005-  
    • Assistant Professor, University of Southern California, 09/01/1999-05/01/2005  

    PostDoctoral Appointments
    • Postdoctoral Research Fellow, Massachusetts Institute of Technology, 11/01/1994-08/31/1999  

    Other Employment
    • Congressional Science Fellow, American Society for Microbiology, 09/01/1993-08/31/1994  

    Description of Research

    Summary Statement of Research Interests
    Professor Aparicio's research is focused on three related topics: (1) regulation of chromosomal DNA replication and the cell cycle in eukaryotic cells; (2) the role of cell cycle checkpoints in monitoring the integrity of chromosomal DNA replication and linking replication to cell cycle progression, DNA repair, and mitosis; (3) the influence of higher order chromatin structures/modifications (e.g.: heterochromatin) on the activity, timing, or replication origin activation during S phase. Aparicio employs a combination of molecular genetic, biochemical, physiological, and genomic methods in his studies. A full understanding of these mechanisms will provide important insights into the regulation of gene expression and organismal development under normal circumstances and the development of cancer when these processes go awry.
    Research Keywords
    DNA replication, DNA repair, chromatin, checkpoints, cell cycle, replication origins, replication forks, budding yeast, S. cerevisiae, genome
    Research Specialties
    Biochemistry, Molecular Biology, DNA replication, Genetics, S. cerevisiae

    Affiliations with Research Centers, Labs, and Other Institutions

    • USC/Norris Comprehensive Cancer Center, Member, http://ccnt.hsc.usc.edu/





  • Department of Biological Sciences
  • University of Southern California
  • Allan Hancock Foundation Building
  • Los Angeles, CA 90089-0371